Can Mushrooms Help Regenerate Brain Cells? The Science Behind Neurogenesis & Fungi

It sounds like something out of a sci-fi novel: mushrooms that may help regrow brain cells. But emerging research into functional fungi - especially Lion’s Mane, Cordyceps, and even Reishi - suggests this concept isn’t as far-fetched as it seems.

Neurogenesis (the birth of new brain cells) and neuroplasticity (the brain’s ability to rewire itself) are processes we once thought only occurred in youth. But science now tells us the adult brain can repair, regrow, and rewire—given the right support.

So where do mushrooms fit in?

First, Let’s Talk Neurogenesis

Neurogenesis mainly happens in the hippocampus, the area of the brain involved in memory, learning, and emotional regulation. It slows with age, stress, poor sleep, and inflammation - but it never fully stops.

Supporting neurogenesis has been linked to:

• Improved memory and learning

• Better emotional resilience

• Slower cognitive decline

• Enhanced mood and focus

The exciting part? Certain compounds in functional mushrooms appear to stimulate or protect these processes.

Lion’s Mane: The Brain’s Best Friend

Lion’s Mane mushroom (Hericium erinaceus) is the star of the neurogenesis conversation. Its active compounds—hericenones and erinacines—have been shown to stimulate the production of Nerve Growth Factor (NGF), a protein essential for neuron growth and repair.

In a 2008 study, researchers found that Lion’s Mane extract significantly boosted NGF production in brain cells.

A follow-up 2009 clinical trial showed that older adults with mild cognitive impairment experienced significant improvements in mental function after taking Lion’s Mane for 16 weeks.

Note: Animal studies have also shown increased hippocampal neurogenesis, improved memory, and even reduced symptoms of depression with regular Lion’s Mane supplementation.

Cordyceps: Boosting Brain Energy

While best known for physical endurance and oxygen uptake, Cordyceps militaris also supports brain cell health. It increases ATP (cellular energy) production, helping neurons fire more efficiently.

In animal studies, Cordyceps has been shown to improve memory, learning speed, and neuroprotection, particularly in models of cognitive decline and oxidative stress.

A 2016 study in Biotechnology and Bioprocess Engineering found Cordyceps improved memory performance and reduced brain inflammation in mice source.

Reishi: Protecting the Brain While You Sleep

Reishi (Ganoderma lucidum) may not spark neuron growth in the same way Lion’s Mane does—but it’s a powerful ally for protecting existing brain cells from damage.

With high antioxidant and anti-inflammatory activity, Reishi helps reduce oxidative stress, a key factor in age-related cognitive decline and impaired neurogenesis.

In models of Alzheimer's and Parkinson’s, Reishi extracts have shown neuroprotective effects, helping prevent the loss of dopaminergic neurons and supporting cognitive stability over time.

Read more on Reishi’s brain effects here

How to Support Brain Cell Regeneration with Mushrooms

Here’s how to bring these fungi into your daily life:

✔ Choose high-quality extracts

Look for fruiting body (not mycelium), dual-extracted, and ideally third-party tested products to ensure the active compounds are present.

✔ Stay consistent

Neurogenesis isn’t instant. Most studies showing benefit involve daily use over weeks or months. Mushrooms are subtle but cumulative.

✔ Stack with brain-loving habits

For best results, combine mushrooms with:

• Movement (especially aerobic exercise)

• Meditation and mindfulness

• Deep sleep and circadian rhythm care

• Learning new skills or languages

• DHA & omega-3s from diet or algae-based supplements

So, Can Mushrooms Regrow Brain Cells?

The early science says yes—in a sense. They don’t work like magic wands, but functional mushrooms can support the brain’s natural regenerative abilities, protect against damage, and help you feel clearer, calmer, and more focused over time.

Neurogenesis is real. And the forest, it seems, has been quietly cheering it on all along.

Curious to try? Our ‘Clarity’ blend features Lion’s Mane, Cordyceps, and adaptogens designed to support focus, memory, and cognitive regeneration.